Founded in 2021, the Maulers were one of the eight inaugural teams for the re-launch of the original United States Football League which ceased operations in 1986.

On December 19, 2023, the USFL informed its players union that the Maulers would not be included in the league's upcoming merger with the XFL.

The team begun the season 0–4, the worst in the league, but defeated the Houston Gamblers 21–20 behind an off the bench effort by newly signed quarterback Vad Lee.

[10] Vad Lee 2022 Note: The Finish, Wins, Losses, and Ties columns list regular season results and exclude any postseason play.

The Pittsburgh Maulers shared a rivalry with their cross-state foes the Philadelphia Stars called the Key Stone State Battle.