The Pittsburgh Subdivision is an American railroad line that is owned and operated by CSX Transportation in the Commonwealth of Pennsylvania.

The line runs from McKeesport (PLY 15.1) northwest through Pittsburgh to West Pittsburg (near New Castle)[2] along a former Pittsburgh and Lake Erie Railroad line.

Its east end is at Sinns (PLY 16.9), across the Youghiogheny River from McKeesport at Liberty, at the west end of the Keystone Subdivision.

[3] [4] Amtrak's Capitol Limited uses the line southeast of Rankin.

In 1934, the Baltimore and Ohio Railroad began operating through trains via trackage rights over the P&LE between McKeesport (slightly north of the current beginning of the Pittsburgh Subdivision until the bridge at Sinns opened in 1968[6]) and New Castle, leaving the P&W Subdivision for local trains only.