The Pixley ka Seme District Municipality (Afrikaans: Pixley ka Seme-distriksmunisipaliteit; Xhosa: uMasipala weSithili sase Pixley ka Seme) is one of the five districts of the Northern Cape province of South Africa.

The seat of Pixley ka Seme is De Aar.

As of 2011, a majority (77%) of its 186,351 residents speak Afrikaans as a first language.

It is named after Pixley ka Isaka Seme, one of the founders of the African National Congress.

Pixley ka Seme is surrounded by other districts as follows: The district contains the following local municipalities: The following statistics are from the 2011 census.