He then spent eight seasons for Benfica, making 360 appearances, scoring 93 goals and winning ten domestic honours including four Primeira Liga titles, three of which consecutively.

Pizzi made his senior international debut for Portugal in 2012 and was part of their squad at the 2017 Confederations Cup and 2018–19 UEFA Nations League, winning the latter tournament.

[9][10] He made his La Liga debut on 18 September 2011, replacing also newly signed Radamel Falcao midway through the second half of a 4–0 home win against Racing de Santander.

[11] He scored his only Atlético goal to open a 3–2 win over Levante also at the Vicente Calderón Stadium on 20 November,[12] totalling 15 appearances of which three were in the victorious UEFA Europa League campaign.

[14] On 26 July 2013, Pizzi signed a six-year contract with Benfica, for a fee of €6 million for half of his economic rights,[15] being immediately loaned to Espanyol also in Spain's top flight.

[28] Pizzi scored twice in the 2019 Supertaça Cândido de Oliveira on 4 August, a 5–0 win over city rivals Sporting CP at the Estádio Algarve.

[31] On 16 December 2020, Pizzi made his 300th Benfica appearance in a penalty shootout win over Vitória de Guimarães in the league cup quarter-finals; he scored a late spot-kick to draw the game 1–1.

[33] On 8 February 2022, after a controversial discussion and conflict with manager Jorge Jesus, Pizzi was loaned to İstanbul Başakşehir until the end of the Turkish Süper Lig season.