The three-story gallery is located in the Short North and Victorian Village neighborhoods, on the eastern edge of Goodale Park.

The Pizzuti Collection opened in 2013, and had shown 16 temporary exhibits before its 2018 donation to the Columbus Museum of Art.

The museum primarily exhibits the Pizzuti family's collection, estimated in 2018 at about 2,400 works of contemporary art.

[2] Ron Pizzuti began his interest in art during a visit to Paris, admiring a work by Frank Stella.

[1] The Pizzuti, along with the main branch of the museum, temporarily closed beginning in March 2020 due to the 2020 coronavirus pandemic.