From the 17th century to the 18th century his family was heir to the famous Majorat or " El Mayorazgo de la Colonas" established in Pontevedra, Spain by his ancestors D. Miguel Henríquez Flores and Dª.
In the mid 18th century, his family settled in the northern Mexican city of Culiacán, Sinaloa which was then New Spain, and became the major political and commercial influence of Northern Mexico.
Although members of his family had previously held his position as Sinaloa governors, he prevented his relatives from having access to politics (with major consequences) when he became governor at the age of 29.
In 1864, General Plácido de la Vega, by then a 3rd division central army General, was sent by Juárez on a secret mission to California, to meet with leading Mexican-American families of Contra Costa to seek support for the constitutional government of Mexico and the movement for independence.
As an officer of the Union Club, he contributed both time and money working on Abraham Lincoln's 1864 re-election.