[1][2] Ischemic placental disease leads to the attachment of the placenta to the uterine wall to become under-perfused, causing uteroplacental ischemia.

Where the term overarches the pathology associated with preeclampsia, placental abruptions and intrauterine growth restriction (IUGR).

[4] Abnormalities present within the spiral arteries lead to higher velocities in blood, in turn causes the maternal villi to shred.

[5] Which trigger pro-coagulator molecules to be released into the blood stream causing action of the coagulator cascade, eventually leading to placental infarction.

Associative prevention mechanisms can be a method of minimising the risk of developing the disease, within early stages of pregnancy.

[7] The abnormal spiral arteries lead decreased level of oxygen diffusion through the placental villus,[5] which cause chronic hypoxia.

Examples include: In placental disease, there's abnormalities present within the spiral arties of the uterus, where the terminal part of the spinal arteries does not dilate.