The PGF gene is expressed only in human umbilical vein endothelial cells (HUVE) and the placenta.

The extravillous trophoblast cells produce a blood vessel of larger diameter for the developing fetus that is independent of maternal vasoconstriction.

Under normal physiologic conditions, PGF is also expressed at a low level in other organs including the heart, lung, thyroid, and skeletal muscle.

In addition, placental sFlt-1 levels were significantly increased and PGF decreased in women with preeclampsia as compared to those with uncomplicated pregnancies.

Studies have found low levels of PGF in women who were diagnosed with preeclampsia later in their pregnancy.

This disease is characterized by an alteration in the PGF gene and its GPCR and ERK signaling pathways.