The plague was an epidemic that devastated the western provinces of the Sasanian Empire just before the Arab Invasion, mainly Mesopotamia (Asorestan), killing half of its population,[3] including the reigning Sasanian king Kavad II, who died in the fall of 628 CE, only a few months into his reign.
[5] The Plague of Shiruye was one of several epidemics that occurred in or close to Iran within two centuries after the first plague pandemic was brought by the Sasanian armies from its campaigns in Constantinople, Syria, and Armenia.
When the Arabs invaded during the reign of Yazdegerd III, the Sasanians had no strength to repel them and so the Plague of Shiryue is recognized as contributing to the decline and fall of the Sasanian Empire.
[7] Note also the climate crisis that occurred between 626 and 629 AD, probably due to a volcanic eruption and ashfall at Constantinople.
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