The school was segregated during the Jim Crow-era and served African American students.

[3][1] The Plaisance School has been listed on the National Register of Historic Places since 2004, for the school's contribution to educational history and Black ethnic heritage.

[1] Merline Pitre, is an alumna and taught French at the school.

Opelousas students in grades five through eight take classes in the historical classrooms.

[9] In 2017, the school reopened after suffering damages in a flood and, in early 2022, plans to restore and repair the historic Rosenwald structure were set into motion.