It serves as a major north–south through street across the west side of the Cow Neck Peninsula, between Northern Boulevard (NY 25A) to the south and Stonytown Road and North Plandome Road to the north, and is the main thoroughfare in downtown Manhasset.

[4] At this location, ownership and maintenance shifts to the Village of Plandome Manor Department of Public Works.

[1][4] It then travels north-northwest and thence veering north-northeast for a short distance, hugging the shore of Leeds Pond until reaching Rock Hollow Road, which provides access to the Leeds Pond Preserve and the Science Museum of Long Island.

[5][10] Additionally, the road passes North Hempstead Town Hall, a nationally designated landmark.

[11][12] Furthermore, Mary Jane Davies Green is located off Plandome Road, across the street from North Hempstead Town Hall, on the site of the Manhasset Union Free School District's former Plandome Road School.