The station was added to the U.S. National Register of Historic Places on November 12, 1993.

The Illinois Zephyr stops in the morning (to Chicago Union Station) and in the evening (to Quincy).

The Carl Sandburg stops in the morning (to Quincy) and the evening (to Chicago).

The rectangular Chicago, Burlington and Quincy Railroad Depot in Plano is constructed in a combination of Classical Revival and American Craftsman architectural styles.

The station was also featured in the 2013 Superman movie, "Man of Steel", which was filmed in Plano.