Students at Plano Senior typically attended one of two feeder high schools: Clark or Vines.

[5] In 1975, the school moved to a new 96-acre (39 ha) campus with five buildings, very similar to the layout of a junior college, where it has remained since.

In July of that same year, the citizens approved a fifty cent tax for school purposes[11] and for the purchase of the Plano Institute's land and building.

[5] However, the affiliations, coupled with the high standards of Plano schools, led to a large number of graduating students going on to attend college.

The Review goes on to state that "no town in Texas, in proportion to its size, has more students in higher institutions of learning than Plano.

The students went to classes in the local Opera House until the completion of the new building, often called the "Spanish School" because of its Moorish architecture.

Following its construction, the district built various new facilities to support its students, including a new band hall, gymnasium, and auditorium.

In 1935, while the country was in the midst of the Great Depression, the WPA offered to build the district a much-needed new gym.

[5] The US$125,000 ($2705673.76 according to inflation) building, completed in 1938, was used as a gym, auditorium, classroom, and laboratory, allowing new subjects to be taught, including agriculture, business, and home economics.

[11] At the time, Texas required that students complete 16 credits, or full semester courses, to graduate.

Twice, in 1955 and 1957, when asked if they favored integration, the citizens on the committee stated they "were perfectly happy with their school and would like to be left alone."

The Texas Education Agency later praised the district for its handling of integration, calling it "an exceptional job.

"[5] In the 1970s, in response to massive growth and with a desire to lower dropout rates and increase college readiness, then Superintendent H. Wayne Hendrick began a search for a new way to organize the school system.

The plan created a 96-acre (39 ha) site with five buildings, very similar to the layout of a junior college.

The new senior high school offered a broad variety of studies previously unseen in the district.

Plano currently offers vocational courses including those in agriculture, family and consumer science, journalism, fashion design, advertising design, drafting, automotive technology, automotive paint and body, clinical rotation, and criminal justice.

The usual range of athletic and music organizations are there for students to join, in addition to Plano's other clubs.

[24] This is the number used by the UIL when determining what other schools Plano competes against in all UIL-sponsored athletic and academic competitions.

[26] At the 2007 National Speech Tournament, Plano students won the sixth place Sweepstakes Trophy.

[34] The Plano boys' and girls' cross country teams have both seen success, including sending Scott McPherson to the 2004 Locker Championship.

In 2012, the Plano Senior High School A Cappella Mixed Choir was announced to represent the state of Texas at ACDA.

In addition, the Plano Senior High School Varsity Men's Choir represented the state of Texas at ACDA in 2017.

In 1955, Plano hired University of Arkansas graduate Emmitt Clem, who led the band for twenty-one years and wrote the school song.

In June 1976 the Plano band traveled to Washington DC and played on the steps of the US Capitol during national bicentennial events.

The band performed in the 1977 State high school championship football game at Texas Stadium where Plano beat Port Neches Groves 13–10.

[38] The Jazz Band at Plano was chosen to attend the Essentially Ellington Competition in New York City in both 2005 and 2010.