It is located in the transition between the Nearctic and Neotropical realms and encompasses parts of the Sierra Madre del Sur, with a wide range of altitudes, climates and soils.
As of 1995 almost 8,000 people lived in the Sierra de Manantlán Reserve, engaged mainly in agriculture (corn, beans, tomatoes, sugar cane, watermelon, mangoes), livestock grazing, timber production, and extraction of wood for fuel and mining of coal or minerals.
These characteristics explain the high biodiversity and the presence of numerous plant formations ranging from tropical forests to temperate-cold climates.
In terms of herpetofauna, 85 species have been recorded; of these 13 are endemic to the western and central region of Mexico: rattlesnake, black iguana, frog Shyrrhopus modestus, beaded lizard (Heloderma horridum) and the Autlan rattlesnake (Crotalus lannomi), an endemic species only reported for the area of Puerto de Los Mazos.
The herbarium web pages at the National Autonomous University of Mexico[3] and at the Missouri Botanical Garden[4] are used as authorities for names with adjustments for the system in use by Wikipedia.