The Plauen–Cheb Line is a mainline railway in Saxony, Germany and the Czech Republic, which was originally built and operated by the Kgl.

It runs from Plauen im Vogtland through Weischlitz, Adorf und Bad Brambach over the national border to Cheb.

To overcome the height difference between the Saxon-Bavarian Railway and the floor of the White Elster valley a considerable amount of earth had to be moved.

After the First World War when Czechoslovakia was formed, the whole line remained in the control of the Royal Saxon State Railways and the subsequent Deutsche Reichsbahn.

At the end of the war on 9 July 1945, the section in the Czech Republic passed over to the Czechoslovak State Railways ČSD.

Cross border goods traffic resumed in 1957, and passenger trains in the Czech section between Plesná and Cheb.

From the start of the 1960s crossborder passenger trains resumed, then an express DR Class VT 18.16 Karlex from Berlin to Karlovy Vary.

RegionalExpress-trains of the Deutsche Bahn ran from Leipzig to Bad Brambach, but on the introduction of the Karlex, in the mid-1990s there is no longer a need for this service.

Shortly before the final station in Cheb, the line passes over the imposing Ohře viaduct, one of the largest bridges built by the Royal Saxon State Railways.