It features guest vocals from Puerto Rican-American female duo Nina Sky and American rapper B-Real.

The track was written by Natalie Albino, Nicole Albino, Vladimir Felix, Louis Freeze, Stephen Hague, Joseph Hernandez, Malcolm McLaren, Ronald Larkins, Robert Andrews and Tyrone Price.

It was released digitally on September 25, 2005 as the lead single from the album, preceding "Saca La Semilla" with Ivy Queen and Gran Omar.

[5] "Play That Song" was written by Natalie Albino, Nicole Albino, Vladimir Felix, Louis Freeze, Stephen Hague, Joseph Hernandez, Malcolm McLaren, Ronald Larkins, Robert Andrews and Tyrone Price.

[7][8] The song features guest vocals by Nina Sky and B Real of Cypress Hill.

[23] This made Nina Sky two of only a few female artists who have been able to reach the Top 10 of the Latin Rhythm Airplay chart along with Ivy Queen, who currently has seven top-ten, two of them number-one singles, Latin pop singers Shakira and RBD, and American R&B singers Beyoncé Knowles, Cassie, and Keyshia Cole.