The Playhouse Theatre was a Broadway theater at 137 West 48th Street in midtown Manhattan, New York City.

It was built in 1911 for producer William A. Brady who also owned the nearby 48th Street Theatre.

Sauce for the Goose was the opening production on April 15, 1911, closing after 2 performances that day.

The Playhouse Theatre was used for interiors and exteriors in the Mel Brooks film The Producers (1967) to depict the staging of the musical Springtime for Hitler, and the exterior was shown as the venue for the last Broadway appearance of the fading star Neely O'Hara in the film Valley of the Dolls (1967).

In 1969, the Playhouse Theatre was razed to accommodate the construction of 1221 Avenue of the Americas.