"Please Excuse My Hands" is the second single from Plies's second album, Definition of Real.

It features Jamie Foxx and The-Dream.

The video was released on July 23, 2008.

It premiered as the "New Joint of the Day" on BET's 106 & Park.

The video is about a man expressing how when he is alone with his lover, his hands have a mind of their own, and he does not intend disrespect to her.