Pleudihen-sur-Rance (French pronunciation: [plødi.ɛ̃ syʁ ʁɑ̃s], literally Pleudihen on Rance; Breton: Pleudehen) is a commune in the Côtes-d'Armor department of Brittany in northwestern France.

It is known for the production of apples and Breton champagne (cider).

During the latter half of the 18th century, the town took in a large share of 2,000 Acadians who were deported to France against their will.

The Musée de la Pomme et du Cidre (The Apple and Cider Museum), located in a farmhouse within town, is a prominent attraction, displaying various types of apple trees, production methods, and offers cider tasting.

Pleudihen-sur-Rance maintains a town partnership with the German community of Herschbach in the Westerwaldkreis, Rhineland-Palatinate.