Pliezhausen (Swabian: Bliazhausa) is a municipality in the district of Reutlingen in Baden-Württemberg in Germany.

After the incorporation of Rübgarten on May 9, 1975, the current municipality Pliezhausen was formed.

From 1635 led the Thirty Years' War to further devastation and death.

The town originally belonged to Oberamt Urach and came in 1842 to Oberamt Tübingen and in the context of Baden-Württemberg district reform in 1973 to the district Reutlingen.

The Martinskirche in Pliezhausen was built in the 11th or 12th century as a Romanesque chapel.