Ploufragan (French pronunciation: [plufʁaɡɑ̃]; Breton: Ploufragan) is a commune in the Côtes-d'Armor department of Brittany in northwestern France.

Ploufragan lies adjacent to the southwest of Saint-Brieuc, the prefecture and largest city of Côtes-d'Armor.

Inhabitants of Ploufragan are called ploufraganais in French.

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