The Plymouth State Panthers football team represents Plymouth State University in college football at the NCAA Division III level.

The Panthers are members of the Massachusetts State Collegiate Athletic Conference, fielding its team in the Massachusetts State Collegiate Athletic Conference since 2013.

[3] Plymouth State claims 14 conference titles, the most recent of which came in 2017.

† Co-champions Plymouth State claims 3 division titles, the most recent of which came in 1990.

† Co-champions The Panthers have made five appearances in the Division III playoffs.