Diphylleia grayi, the skeleton flower, is a species of perennial plant in the family Berberidaceae.

The flowers are white, pedicellate, with six obovate petals and bloom from May to July.

[3] After it flowers, it bears dark blue/purple fruit with a white powdery coating from June to August.

[5] The plant is distributed from north to central Honshu, Hokkaido, Mount Daisen, and Sakhalin.

[6][7] In the 1960s, botanist Yanagi Kimura discovered that D. grayi crude extracts contain substances similar to, but more powerful than podophyllin and colchicine.