Podophyllum peltatum is a North American herbaceous perennial plant in the family Berberidaceae.

[5] Mayapples are woodland plants, typically growing in colonies derived from a single root.

[11] Plants are commonly found infected by the rust Allodus podophylli, appearing as honeycomb-patterned orange colonies under the leaves, and yellowish lesions on the upper surface.

[citation needed] The ripened yellow fruit is edible in small amounts and is sometimes made into jelly.

[citation needed] Mayapple can be used topically as an escharotic in removing warts, and two of its derivatives, etoposide and teniposide, have shown promise in treating some cancers.