The series centers on the DC Comics villain Poison Ivy who, following the events of the "Fear State" crossover, finds herself depowered and dying.

[2] Poison Ivy was originally intended to be a six-issue miniseries written by G. Willow Wilson with art by Marcio Takara, coloring by Arif Prianto, and lettering by Hassan Otsmane-Elhaou.

[8] Poison Ivy's villainy is often motivated by a desire to protect the natural environment from man-made destruction, and the climate change crisis is at the forefront of the story.

[12] Reviewing the first issue, Bleeding Cool's James Hepplewhite wrote that it was a promising start,[13] while ComicBook.com's Nicole Drum thought it was "very close to perfect" but did not like how Ivy and Harley's relationship was portrayed.

[14] In their reviews of the second issue, both Drum and AIPT Comics' David Brooke praised the complex and humanized version of Ivy presented by Wilson.