In 1972, while attending Sacramento State College, Wallace met future Cramps singer Lux Interior.

The Cramps, with Ivy, Lux, and various other guitarists, drummers, and bassists, continued to release records and perform live until the fall of 2006, enjoying some commercial success (mainly in Europe) and acquiring a strong cult following worldwide.

She produced or co-produced several of their albums and singles, sang on the songs "Kizmiaz" and "Get Off the Road," and played theremin on later records.

Songs written by Ivy and Interior and performed by other artists include "Human Fly" (which is based on "Do the Fly" performed and written by Ray Gentry/Rovin' Gamblers [1961], modified by The Cramps [calling it "Human Fly", 1978], but without credit to the original) [6] (Sinful Lilly, Crestfallen, The Dead Brothers, Nouvelle Vague, Supernaut, Hanni El Khatib, Los Esquizitos [a Mexican garage band] covered Human Fly as El Moscardón); "New Kind of Kick" (The Jesus and Mary Chain, The Drones, Muse, Tinfed); and "Thee Most Exalted Potentate of Love" (Queens of the Stone Age).

She used Fender Pro Reverb amplifiers onstage, and smaller Valco and Allen amps in the studio.