The hospital later became a charity organisation, and extended its services to include schools, homes for the elderly, social welfare and other areas.

A local shop owner, Wong Shu-kiu, reportedly conceived the hospital idea in 1913, and a village elder supported it.

[3] The smallest voluntary hospital, when use of HK$3500 to build, provided free medical services and burials.

[9] On 27 March 1984 a major part of the second phase of the expansion was completed, with five new storeys added to the central block, contributing 113 more beds (for a total of 331) and another operating theatre.

Tin Shui Wai New Town was developed nearby in the 1990s, increasing the burden on Pok Oi Hospital.

To celebrate the centenary of the hospital, Hongkong Post issued a set of commemorative postage stamps on 2 April 2019.