A native of Louisiana, Perritt began his career in Major League Baseball with the St. Louis Cardinals from 1912 to 1914.

He was one of the leading pitchers in the National League from 1914 to 1918, compiling an 81–62 win–loss record and a 2.46 earned run average (ERA) during that period.

[2] Perritt began his professional baseball career in 1912 in the Cotton States League playing for the Vicksburg Hill Billies and the Greenwood Scouts.

[3] Perritt joined the St. Louis Cardinals in September 1912 and compiled a 1–1 record and 3.19 ERA in six games in the closing weeks of the season.

He led the National League with 15 batters hit by a pitch and ranked among the National League leaders with a 2.36 ERA (eighth), .552 win percentage (10th), 93 bases on balls (eighth), a 118 adjusted ERA+ rating (ninth), and a 3.7 wins above replacement (WAR) rating (10th).

[1] Perritt was reportedly "dissatisfied with affairs in St. Louis", and after the 1914 season, he signed a three-year contract to play for the Pittsburgh Rebels of the Federal League.

[1] On September 9, 1916, he won both games in a double-header against the defending National League champion Philadelphia Phillies.

That year, Perritt appeared in 35 games, compiled a 17–7 record and ranked among the National League leaders with a .708 winning percentage (third) and a 1.88 ERA (third).

[1] Despite his strong performance in the regular season, Perritt did not start any games in the 1917 World Series against the Chicago White Sox.

"[2] Perritt held out at the start of the 1919 season, suggesting he may leave baseball to devote his full attention to oil wells that he owned in Texas.

[1][12] He quit the team and went home in August, and a newspaper account at the time reported that Perritt "had been practically useless all season, having been unable to get into condition.

"[13] Despite having appeared in only 19 innings and having left the team early, Perritt appealed to the National Commission for a full share of the Giants' prize money for finishing in second place.

[15] Perritt did appear in four games late in the 1920 season with the San Antonio Bears in the Texas League.