Polazzodus is an extinct pycnodontid from the late Cretaceous (early Santonian) of the Polazzo locality of north-eastern Italy.

The paleoenvironment of Polazzo was a large marine carbonate platform and shallow internal lagoons formed from rudist reefs.

The new genus Polazzodus was erected based on a number of autapomorphies that distinguished it from similar pycnodontid fish.

These include a second dorsal ridge scale (from which the Latin species name, coronatus, is derived), presence of olfactory fenestra on premaxilla, posterodorsal process on cleithrum, and several others.

Polazzodus, being a low-bodied pycnodont, is most similar morphologically to Pycnodus and Tergestrinia, though its body shape is more oval than these genera.