Polina Denisovna Osipenko (Russian: Полина Денисовна Осипенко, Ukrainian: Поліна Денисівна Осипенко, romanized: Polina Denysivna Osypenko; 8 October 1907 – 11 May 1939) was a Soviet military pilot who, with Valentina Grizodubova and Marina Raskova on 24–25 September 1938, performed a nonstop flight between Moscow and the Sea of Okhotsk, setting a new women's nonstop flight distance record.

[3] After graduating from flight school Osipenko subsequently served as military officer, flying a fighter.

[3] In October 1937, she and Raskova set the women's flight distance record by flying from Moscow to Aktobe (1,444.722 kilometres (897.709 mi)), and in July 1938, Osipenko, Vera Lomako, and Raskova set a new record by flying non-stop from Sevastopol to Arkhangelsk in a Beriev MP-1.

[4] On 24 September, Grizodubova, Osipenko, and Raskova set on what was supposed to be a non-stop flight from Moscow to Komsomolsk-on-Amur in a Tupolev ANT-37.

Because of difficult weather conditions, they missed the Komsomolsk airfield, and found themselves at the shore of the Sea of Okhotsk without any fuel left.