The Polk Sisters' House is a historic house in Columbia, Tennessee, that was the home of two sisters of U.S. President James K. Polk.

Ophelia Polk Hayes was born September, 6 1812 in Maury County, and married Dr. John B. Hayes on September, 25 1829 in Columbia, TN.

The Hays/Hayes family has lived in middle Tennessee since moving from Virginia (following the Revolutionary War).

The Polk Sisters' House is next door to the James K. Polk Home and houses its visitors' center, museum room, and gift shop.

This article about a property in Maury County, Tennessee on the National Register of Historic Places is a stub.