When he returned to work on TV his fame had grown exponentially, even internationally, which is why his next series, Naranja y media was translated into English and broadcast in several countries under the title My Better Halves.

His next movie, Un Argentino en New York, was filmed in Spain and United States; starring alongside the Uruguayan actress/singer Natalia Oreiro, it became one of the greatest Argentine cinema hits.

On this occasion, he had to play three Buenos Aires brothers, Luigi, Marcelo and Enzo, that integrated a classic family of Italian roots, but in turn, each with a different personality that characterized them.

In 2000 he filmed Papá es un ídolo it was translated in English with the name of Daddy is My Idol in this movie Manuel Bandera and Millie Stegman.

There he shared the cast with Gabriel Goity, Alberto Fernández de Rosa, Roberto Carnaghi, Florencia Peña, Andrea Frigerio, Mariana Briski, Manuel Wirtz, René Bertrand, Toti Ciliberto and Cecilia Milone and with newly emerged models such as Pamela David, Luciana Salazar and Julieta Prandi.

During these two years, he starred with Enrique Pinti at the Lola Membrives theater in Buenos Aires and then at the Auditorium Mar del Plata the musical comedy The Producers, a great success with both the public and critics.

In 2008, he made a special participation in the final chapter of the soap opera Vidas robadas which won the Martín Fierro de Oro Award 2008.

In 2009, he starred alongside Ricardo Darín and Soledad Villamil in El secreto de sus ojos which sold approximately two million tickets and became the most watched movie of the year, as well as the second most successful national film of all time in its country.

In 2011, he returned to the small screen with the TV comedy El hombre de tu vida, where he played the role of Hugo, a man affected by a midlife crisis who decides to work professionally as a gigolo.

In 2012 saw the premiere of the comedy film ¡Atraco!, starring Francella alongside Nicolás Cabré and Amaia Salamanca under the direction of Eduard Cortés, playing a fictional Peronist named Merello.

In 2014, he starred with Inés Estévez and Alejandro Awada in the comedy-drama El misterio de la felicidad, directed by Daniel Burman.

In addition, Francella returned to the theater and starring along Adrián Suar in Dos pícaros sinvergüenzas, where he plays Lawrence Williams, a man who scams women together with his partner.