The structure was listed in the National Register of Historic Places on 4 June 2012.

In 1919 efforts and surveys were made to start YMCA work in Ponce.

As a result of these difficulties, affiliation with various statewide YMCA organizations was sought in 1944, and again in 1947.

[1] The Ponce YMCA was listed in the National Register of Historic Places on 4 June 2012.

[2] Its listing was made possible in part for its interior mural by Rafael Rios Rey titled "El Hombre" (English: Man).