Ponce de Leon is an unincorporated community in northeastern Stone County, Missouri, United States, approximately 30 miles (50 km) south of Springfield.

The community is located on the East Prong Goff Creek, which is a tributary of the James River about three miles to the west.

[1] The community was founded circa 1875 as a health resort to exploit the mineral spring at the location.

However, the boom did not last and by 1885, damage by flash floods and other economic problems led to decay and loss of population.

[2] Area residents refer to the community as "Poncie"; for years, use of the full name has virtually been abandoned.