Pone Kingpetch turned to professional boxing and won the Thai flyweight title with a TKO victory over Kunoi Vithichai in April 1956.

In January 1957, Pone Kingpetch defeated Danny Kid in Bangkok to win the OPBF flyweight title.

However, his second reign proved to be short, as Hiroyuki Ebihara knocked Pone out in the first round to become the new world flyweight champion.

In On February 14, 1963, with the creation of the World Boxing Council, Kingpetch was named the inaugural WBC flyweight champion.

In his final title win he defeated Ebihara in a rematch on January 23, 1964, to become a three-time world flyweight champion.

This resulted in rotting and blood poisoning, leading to Kingpetch's health deteriorating significantly as he was already suffering from both a cold and pneumonia.