As one of the few Hong Kong schools with over a hundred years of history, it aims at nurturing young women to "speak confidently and think critically in bilingual learning environment".

Missionary Emma Young, sent by the Foreign Mission Board based in USA, set up ‘Pooi To Academy’ in Guangzhou.

In 1937(during World War II), an air raid occurred in Guangzhou after Lugouqiao Incident.

However, Hong Kong was occupied by the Japanese a year later, and Pooi To Middle School was then moved to Macau.

37 Grampian Road, Kowloon City, where the campus was shared by primary and secondary school students.

In 1952, the school successfully applied for the land in 2-8 Inverness Road to build a new campus, which was later officially opened by Madam Grantham (Maurine Samson, wife of Hong Kong Governor, Sir Alexander Grantham) on the opening ceremony.

Four years later, in 1965, students sat for HKCEE (Hong Kong Certificate of Education Examination) and the passing rate was 95%.

The school aims at nurturing students to become loving, honest, pure and persevering girls.

The facilities include : The four-leaf clover in the middle of the school emblem symbolizes love, faith, hope and blessing.

[2] In the 2015 HKDSE (Hong Kong Diploma of Secondary Education), students of Pooi To Middle School achieved remarkable results.

The percentages of number of students achieving level 2 in 15 subjects were higher than the overall average of Hong Kong.