Poopó is a province in the eastern parts of the Bolivian department of Oruro.

The province lies east of the Desaguadero River and Poopó Lake.

In addition to Spanish, 78% of the population speak Quechua and 22% Aymara (1992).

61% of the population are employed in agriculture, 12% in mining, 5% in industry, 22% in general services (2001).

The province comprises three municipalities which are further subdivided into cantons.