[3] Jeffrey Richards describes him as "the last survivor of the Symmachan old guard", having been ordained as a deacon perhaps as early as 502, during the Laurentian schism.
His first official act was to burn, in the presence of the assembled clergy, the anathema which Boniface II had pronounced against the latter's deceased rival Dioscurus on a false charge of simony and had ordered to be preserved in the Roman archives.
He confirmed the decrees of the Council of Carthage, after the retaking of North Africa from the Vandals, according to which converts from Arianism were declared ineligible to Holy Orders and those already ordained were merely admitted to lay communion.
He accepted an appeal from Contumeliosus, Bishop of Riez, whom the Council of Marseilles had condemned for immorality, and he ordered Caesarius of Arles to grant the accused a new trial before papal delegates.
King Theodahad of the Ostrogoths begged Agapetus to proceed on an embassy to Constantinople and use his personal influence to appease Emperor Justinian I following the death of Amalasuntha.
"[2] Agapetus, for the first time in the history of the Church, personally consecrated Anthimus' legally elected successor, Menas.
Justinian delivered to the Pope a written confession of faith, which the latter accepted with the proviso that "although he could not admit in a layman the right of teaching religion, yet he observed with pleasure that the zeal of the Emperor was in perfect accord with the decisions of the Fathers".
On the Clivus Scauri the archeological remains known as the 'apsidal Hall of the Library of Pope Agapitus I' is located near the ancient Church of St. Andrew on the Caelian Hill.