Pope Anastasius I was the bishop of Rome from 27 November 399 to his death on 19 December 401.

He succeeded Siricius as pope and condemned the writings of the Alexandrian theologian Origen shortly after their translation into Latin.

During his reign, he also encouraged Christians in North Africa to fight Donatism.

[2] He instructed priests to stand and bow their head as they read from the gospels.

[4] He died in Rome[5] and was eventually buried in the Catacomb of Pontian together with his immediate successor, Innocent I. Jerome also referred to Anastasius as Innocent's father, although scholars have argued this was displaying a hierarchical relationship rather than a biological one.