In addition to pastoring the church, he wrote many epistles and discourses, including a reaffirmation of the miaphysite and non-Chalcedonian views.

However, the Chalcedonian patriarch, probably Gregory of Antioch, discovered the plan and prevented it, forcing Damian and his colleagues to flee.

[1] Damian then went to Constantinople, where he consecrated some bishops and took part in a church council, which he later repudiated.

[1] The Synaxarium entry for Damian recounts the following two theological controversies in which he was involved:[3] Damian was very active in fighting views that he considered heretical, including not only tritheism, but also the Chalcedonians, Pope Leo's Tome, Bishop Julian of Halicarnassus, the Agnoetae, the Melitians, the Acephali, the Gaianites (supporters of a rival to Theodosius I), Stephen of Alexandria and Paul of Beth Ukame.

[1] The Barsanuphians split from the Acephali during the time of Damian and established their own episcopal hierarchy.