Incumbent Governor Aníbal Acevedo Vilá faced no opposition for his candidacy, making him the official candidate for the elections.

Also, one of the most contested campaigns was the one for Mayor of Ponce, with incumbent Francisco Zayas Seijo facing the former administrator of the city, Carlos Jirau.

Several weeks after the primaries, Incumbent Governor and PPD candidate, Aníbal Acevedo Vilá, was officially indicted on 19 counts of campaign finance violations.

However, Acevedo Vilá decided to run for reelection, and was openly endorsed by the Party in a massive caucus held at the José Miguel Agrelot Coliseum in April 2008.

[4][5] At the 2008 general elections, both Zayas and Jirau were defeated by the PNP candidate Mayita Meléndez.