[1][2] The PRB works in the United States and internationally with a wide range of partners in the government, nonprofit, research, business, and philanthropy sectors.

[8] The PRB's online data allows users to search a database of hundreds of demographic, health, economic, and environmental variables for countries and regions all around the world, such as the Middle East, Latin America, and Sub-Saharan Africa.

The database provides scholarly articles about an assortment of topics, ranging from noncommunicable diseases and nutrition to the labor force and family planning.

[3] The Population Reference Bureau has both past and current programs and service projects around the globe, mainly focused in the United States, and parts of the developing world including Sub-Saharan Africa and the Middle East.

[11] Current projects of the Population Reference Bureau include; Demographic and Socioeconomic Trends in the Appalachian region of the United States, Combatting Noncommunicable Disease Risk Factors in Youth across Latin America and the Caribbean, North Africa and the Middle East, Asia, and Africa, and their current featured project; Evidence to End Female Genital Mutilation/Cutting across the globe.