Port-Louis (French pronunciation: [pɔʁ lwi] ⓘ; Guadeloupean Creole: Pòlwi) is a commune in the department of Guadeloupe, on the northwest of Grande-Terre.

The settlements in the commune of Port-Louis include Beauplan, Beauport, Beautiran, Bellevue, Belin, Belthier, l'Ermitage, Fauvette, La Goguette, Lallanne, Monroc, Pelletan, Philipsbourg, Pichon, Pierre-Ferraye, Paul-Aubin, Pouzzole, Rodrigue, Saint-Pierre, and Sylvain.The settlement of northern Grande-Terre began in the mid-17th century.

In the 19th century, the Domaine de Beauport was one of the most important sugar factories in the French West Indies.

Population censuses have been carried out in the commune since 1961 after Guadeloupe was made a French department in 1946.

Since 2014, Port-Louis has belonged to the urban conglomeration of North Grande-Terre, which is made up of 5 communes and has 58 267 habitants (based on 2016 statistics).