[7] Ohio Governor John Kasich signed the bill into law on June 14, 2016, with the name change becoming official 90 days later.

Passengers traveled overnight on the Pennsylvania Railroad's Airway Limited from New York to Columbus; by air from Columbus to Waynoka, Oklahoma; by rail again on the Atchison, Topeka & Santa Fe from Waynoka to Clovis, New Mexico; and by air from Clovis to Los Angeles.

[11] During World War II, most of the facility was taken over by the U.S. Navy, which established Naval Air Station Columbus in 1942.

Also, new hangars and office spaces were completed for NetJets in 1999, as well as a $92 million parking garage including an underground terminal entrance, new rental car facilities, dedicated ground transportation area, improved eight-lane terminal access on two levels, and a new atrium and entrances in 2000, which were designed by URS Corporation.

Columbus began its Terminal Modernization Program in late 2012, which included new terrazzo flooring throughout the airport, new ceilings, new restrooms, more TSA security lanes, and new LED lighting.

This created a buffer distance that enables simultaneous takeoffs and landings on the north and south runways, increasing air traffic volume.

Occasionally, larger aircraft that the airport is not used to receiving on a regular basis, such as the Boeing 767 and 777, are chartered through John Glenn and serviced by Lane Aviation.

Air Canada temporarily suspended service to Columbus, while airlines such as United, American, and Delta used smaller aircraft for some of their mainline routes.

In spring 2023, the airport prepared for a record travel summer matching traffic levels from before the COVID-19 pandemic.

John Glenn Columbus International Airport has one terminal with three concourses, and a total of 29 usable gates.

Additionally, there is a free cell phone lot accessed from the outbound side of International Gateway.

Vernon route is operated from downtown, with every other bus serving either the airport or Easton Transit Center.

[32][33] The GoBus Rural Inter-City Bus Service operates a thrice daily schedule to Athens, via Lancaster, Logan, and Nelsonville.

[36] In November 2006, Skybus Airlines began leasing 100,000 square feet (9,300 m2) of office and hangar facilities at the Columbus International AirCenter adjacent to the airport.

[37] Regional carrier Republic Airways operates a large crew and maintenance base at the airport.

For the same time period, 88 aircraft were based at the airport: 50 jets, 27 single-engine and 9 multi-engine airplanes, and 2 helicopters.