Port Elizabeth Central was a constituency in the Cape Province of South Africa, which existed from 1910 to 1994.

The first challenge to the Cape Qualified Franchise came with the Women's Enfranchisement Act, 1930 and the Franchise Laws Amendment Act, 1931, which extended the vote to women and removed property qualifications for the white population only – non-white voters remained subject to the earlier restrictions.

In 1936, the Representation of Natives Act removed all black voters from the common electoral roll and introduced three "Native Representative Members", white MPs elected by the black voters of the province and meant to represent their interests in particular.

When the UP collapsed in 1977, Port Elizabeth Central elected D. H. Rossouw from the moderate South African Party.

However, in 1981 the seat was won by the more liberal Progressive Federal Party, which would hold it throughout the remainder of its existence.