Port O'Connor is an unincorporated community and census-designated place (CDP) in Calhoun County, Texas, United States, near the Gulf coastline between Galveston and Corpus Christi.

Port O'Connor was laid out in the late 19th century as a fishing settlement called "Alligator Head".

As it grew in popularity with both permanent residents and tourists, the community took on more municipal characteristics, earning the formal designation finally in 1909 as the town site of Port O'Connor.

In 1961, Port O'Connor was in the midst of another growth boom due to the increase of military personnel on nearby Matagorda Island Air Force Base.

[4] That same year, Hurricane Carla destroyed the town again, but times reflect its will to survive, fueled by tourism, commercial fisheries, and the petrochemical industry.