After "La Florida" and "St. Augustine," it is the oldest still-in-use European place name in the United States.

In the 1950s, the land that would eventually become Port St. Lucie was a largely uninhabited tract of land south of White City, composed of a fishing camp (Burt Pruitt's Fishin' Farm) along the St. Lucie River,[13] a few farms and businesses near U.S. 1.

GDC requested the state legislature to incorporate 70 miles (110 km), along with the River Park settlement, into the City of Port St. Lucie.

953, proposed by State Representative Rupert Smith and approved by Florida Governor C. Farris Bryant.

[2][15] In the early 1990s, Core Communities (CC), acquired and began planning what would become St. Lucie West.

The community, which sits west of the Interstate 95 interchange with Gatlin Blvd., was a large cattle ranch before CC began to develop it.

According to CC's website, Tradition is the largest fully entitled residential development area from the tip of Interstate 95 to the Canada–U.S.

That money, combined with a transportation fund and other accounts, would give St. Lucie $20 – $30 million to spend on building projects: research parks, highways and other infrastructure improvements.

[17] In 2008, Tradition and Core Communities welcomed the Florida Center of Innovation (later renamed Tradition Center for Innovation), a 150-acre privately owned research park dedicated to drug discovery, immunology and medical devices, and healthcare.

TCI initially composed of Torrey Pines Institute for Molecular Studies, Oregon Health and Science University's Vaccine and Gene Therapy Institute (VGTI), Martin Health System Hospital (Tradition Medical Center), and Mann Research Center.

In 2017, TAMCO, a subsidiary of City Electric Supply, a family-owned electrical wholesale business, created plans with the Port St. Lucie City Council to construct a $38 million, 400,000 square foot manufacturing and distribution center located in the Tradition Commerce Park.

As of 2020, there are 33 neighborhoods in Port St. Lucie:[21] Port St. Lucie is located in the broad transition zone between a humid subtropical climate (Cfa), which dominates Central Florida, and within the northern extent of the tropical climate typical of South Florida.

On June 3, 2002, the Florida Department of Transportation (FDOT) approved funding, expanding the bus service to Martin County, and became the Treasure Coast Connector.

In 2020, the bus service changed its name to Area Regional Transit (ART); buses run on eight routes, five of which serve Port St.

The Turnpike is 4 lanes wide (2 in each direction), and provides access to Orlando to the north, and Miami to the southeast.

It is 6 lanes wide (3 in each direction), and provides access to Jacksonville to the north, and Miami to the south.

[36] Port St. Lucie is responsible for maintaining approximately 912.5 miles (1,468.5 km) of roadway within its city limits.

Lucie County line to the south to Midway Road at the northern limits of the city.

to the north being the other two), it is also the location of Florida's first superstreet intersection—also known as a "restricted-crossing U-turn intersection"—at Crosstown Parkway and Floresta Drive.

SR 716 – The state road portion of Port St. Lucie Boulevard (commonly shortened to PSL Blvd.)

The Florida East Coast Railway (FEC) mainline passes through the extreme eastern parts of the city.

The Treasure Coast Tritons soccer team also play in the city at the South County Stadium, starting in the 2019 season.

In 2009, the Jr. Midget Pirates went 16–0 en route to winning the Pop Warner National Championship at Disney's Wide World of Sports Complex.

A fictional version of Port St. Lucie is the setting for the Japanese manga and anime JoJo's Bizarre Adventure Part 6: Stone Ocean in which the protagonist is imprisoned in the fictional Green Dolphin Street Prison located just outside of the city.