The Port of Pittsburgh is a vast river traffic region in southwestern Pennsylvania.

It spans a thirteen-county area including Allegheny, Armstrong, Beaver, Blair, Butler, Cambria, Clarion, Fayette, Greene, Indiana, Lawrence, Washington, and Westmoreland Counties.

It encompasses more than 200 miles of commercially navigable waterways in southwestern Pennsylvania, including the three major rivers in this region: the Allegheny, the Monongahela, and the Ohio.

The port complex is served by the CSX and Norfolk Southern railroads and by four interstate highways.

The Port of Pittsburgh Commission acts as a comprehensive service for shippers and industries seeking information on the river system.