[1][2] The building housed nurses for the former adjacent Portland Adventist Sanitarium.

The sanitarium was founded around 1895 when the Seventh-day Adventists rented an eight-bedroom mansion from Simeon Reed, converting it into a six-patient facility.

By 1897, the property was owned by the Seventh-day Adventist Church, which established the vegetarian Portland Sanitarium Food Company as a branch of the Battle Creek Sanitarium Food Company.

[3] Until it was closed for construction, the Nurses' Quarters building housed the Institute for International Christian Communication's WorldView Center, a missionary training program.

[4][5][6] In 2014, the building underwent land use review and rezoning in to be converted into 75 micro-apartments, including seismic retrofits.