Portogruaro (Venetian: Porto, Friulian: Puart) is a town and comune in the Metropolitan City of Venice, Veneto, northern Italy.

Portogruaro was officially founded in 1140, when the Archbishop of Concordia, Gervinus, gave a group of fishermen (Giovanni Venerio, Arpone, Bertaldo, Borigoio, Enrico Mosca, Giovanni Salimbene) the right to settle there and build a river port.

In 1420, after centuries under Patria del Friuli, was conquered by the Republic of Venice.

Apart from a brief uprising in 1848 Portogruaro remained under Austrian control until 1866 when it entered the newly unified Kingdom of Italy.

In the "frazioni" of Lison e Pradipozzo are produced several wines which are exported all around the world: The local football club is called Calcio Portogruaro Summaga, founded in 1990, and plays in the fourth Italian league (Serie D).